Revolutionizing biomedicine: Design of single-cell protein analysis tools at scale

  • Project Year: 2025-26
  • Departments Represented: MEng
  • Industry/Track: Health & Wellbeing

This project develops a microfluidic chip for simultaneous single-cell RNA and protein capture. Cells are settled into indexed PDMS microwells, lysed, and their contents partitioned in parallel — RNA onto magnetic beads and proteins into a polyacrylamide gel via electrophoresis. Spatial indexing preserves cell-to-biomolecule pairing throughout transfer and downstream sequencing and mass spectrometry analysis.

  • Advisor(s): Amy Herr
  • Team: Bhavya Sabbineni [BIOE], Maylee Tan [MSE], Samantha Lee [BIOE]